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  • 產(chǎn)品名稱(chēng):HIF1AN抗原(重組蛋白)

  • 產(chǎn)品型號(hào):1mg
  • 產(chǎn)品廠商:通蔚生物
  • 產(chǎn)品價(jià)格:3580
  • 產(chǎn)品庫(kù)存:35
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詳情介紹:

中文名稱(chēng): HIF1AN抗原(重組蛋白)

英文名稱(chēng): HIF1AN Antigen (Recombinant Protein)

別     名:  FIH1

儲(chǔ)     存:  冷凍(-20℃)

相關(guān)類(lèi)別: 抗原

概    述

Full length fusion protein

技術(shù)規(guī)格

Full name:

hypoxia inducible factor 1, alpha subunit inhibitor

Synonyms:

FIH1

Swissprot:

Q9NWT6

Gene Accession:

BC007719

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

Hydroxylates HIF-1 alpha at 'Asp-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively.





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