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  • 產(chǎn)品名稱：PCP4抗原（重組蛋白）

  • 產(chǎn)品型號：1mg
  • 產(chǎn)品廠商：通蔚生物
  • 產(chǎn)品價格：3580
  • 產(chǎn)品庫存：35
  • 產(chǎn)品文檔：
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根據(jù)數(shù)據(jù)統(tǒng)計 PCP4抗原（重組蛋白）在同類產(chǎn)品中銷量很好，實驗效果顯著。我司具有明顯的價格優(yōu)勢，在保障產(chǎn)品質(zhì)量條件下不斷提升技術降低成本，使各項指標越開越**?？梢詽M足生物化學、分子生物學、細胞生物學、免疫學等生物實驗需求。
詳情介紹：


中文名稱： PCP4抗原（重組蛋白）

英文名稱： PCP4 Antigen (Recombinant Protein)

儲     存：  冷凍（-20℃）

相關類別： 抗原

概     述

Fusion protein corresponding to a region derived from N terminal 61 amino acids of human PCP4

技術規(guī)格

Full name:

purkinje cell protein 4

Synonyms:

PEP-19

Swissprot:

P48539

Gene Accession:

BC013791

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

PCP-4 (Purkinje cell protein 4), also known as PEP-19, is a calmodulin (CaM) regulatory protein that is highly expressed in neuronal cells. Through its IQ motif, PCP-4 mediates both the calcium-dependent binding properties of CaM and the rates of association and dissociation of calcium from the C-terminal domain of CaM. The IQ motif contains a serine residue which can be phosphorylated by all isoforms of protein kinase C (PKC). PCP-4 is implicated in uterine leiomyomas, as well as in neurodegenerative disorders such as Alzheimer’s disease and Huntington's disease. Additionally, overexpression of PCP-4 is thought to play a role in cerebellar hypoplasia, a key feature of Down syndrome.






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